| Third Annual Exhibition of Work by Cleveland Artists and Craftsmen [May Show] | | May | 06 | 1921 | June | 06 | 1921 |
| Etchings and Drypoints by Eileen and George Soper | | November | 16 | 1921 | December | 09 | 1921 |
| Laces: J.[eptha] H.Wade's Recent Accessions | | May | 14 | 1921 | October | 31 | 1921 |
| Special Exhibition of Contemporary Japanese Paintings | Link | June | 08 | 1921 | July | 18 | 1921 |
| Special Exhibition of British Arts and Crafts | Link | June | 09 | 1921 | July | 08 | 1921 |
| Etchings by [Lester G.] Hornby, Troy Kinney and [Arthur W.] Heintzelman | | June | 09 | 1921 | July | 08 | 1921 |
| Paintings selected from local canvases produced in the past ten years and from leading spring exhibitions | | June | 10 | 1921 | July | 10 | 1921 |
| Contemporary American Painting | | June | 10 | 1921 | July | 10 | 1921 |
| Paintings by "The Group of Seven," Canadian Painters | | July | 07 | 1921 | August | 31 | 1921 |
| Etchings by Charles A. Platt | | July | 07 | 1921 | September | 29 | 1921 |
| French Painting of the Latter 19th Century | Link | July | 12 | 1921 | September | 15 | 1921 |
| Second Annual Exhibition of the Art and Craftwork of the Cleveland High Schools | | August | | 1921 | November | 20 | 1921 |
| Etchings and Lithographs by Mary Cassatt and Artists of the Barbizon School | | December | 11 | 1920 | January | 11 | 1921 |
| Prints from the Modern French School | | December | 11 | 1920 | January | 12 | 1921 |
| Musical Instruments, The Charles G. King, Jr. Collection | | December | 29 | 1920 | April | 4 | 1921 |
| Illuminations and Printing from Various Lenders | | January | 08 | 1921 | February | 14 | 1921 |
| Paintings by Arthur H.K. Hammond lent by Dow Chemical Co. | | January | 12 | 1921 | March | 01 | 1921 |
| Loan Exhibition of Etchings by Frank W. Benson | | January | 15 | 1921 | March | 03 | 1921 |
| 17th- and 18th-Century English Rooms | | February | 13 | 1921 | May | 15 | 1921 |
| Korean Pottery, a Few Textiles, and Paintings | | August | 31 | 1921 | October | 03 | 1921 |
