| Paintings by Gaston [de] LaTouche | | April | 02 | 1921 | April | 27 | 1921 |
| Charles Shackleton Memorial Exhibition | | November | 15 | 1921 | December | 25 | 1921 |
| Italian Engravings of the 15th and 16th Centuries | | April | 08 | 1921 | September | 06 | 1921 |
| Etchings and Drypoints by Eileen and George Soper | | November | 16 | 1921 | December | 09 | 1921 |
| Italian Textiles | | April | 16 | 1921 | May | 13 | 1921 |
| Third Annual Exhibition of Work by Cleveland Artists and Craftsmen [May Show] | | May | 06 | 1921 | June | 06 | 1921 |
| Laces: J.[eptha] H.Wade's Recent Accessions | | May | 14 | 1921 | October | 31 | 1921 |
| Western Etchings by George Elbert Burr, Charles W. Dahlgreen, Ralph M. Pearson, and B.[ror]J. Nordfelt | | November | 29 | 1921 | January | 05 | 1922 |
| Etchings of the Dutch Masters | | December | | 1922 | December | | 1922 |
| Special Exhibition of Paintings by Victor Charreton | | January | 01 | 1922 | February | 02 | 1922 |
| Durer | | December | | 1922 | December | | 1922 |
| Miniatures, Water Colors and Bronzes | | January | 03 | 1922 | March | 01 | 1922 |
| Etched Designs for Table China by Felix Bracquemond | | December | | 1922 | December | | 1922 |
| Dutch Graphic Arts | | January | 06 | 1922 | January | 30 | 1922 |
| Etchings by James McBey and Percy Smith | | December | | 1922 | December | | 1922 |
| 18th-Century Mezzotints | | February | 01 | 1922 | March | 21 | 1922 |
| Paintings by Chauncey F. Ryder | | February | 03 | 1922 | March | 01 | 1922 |
| Japanese Prints: Recent Additions to J. H. Wade | | February | 03 | 1922 | March | 18 | 1922 |
| Renaissance Art | | February | 12 | 1922 | April | | 1922 |
| Lithographs by Joseph Pennell and Henri Fantin-Latour | | March | 03 | 1922 | March | 23 | 1922 |
