| Ji Yun-Fei: Last Days of Village Wen | Link | February | 12 | 2016 | July | 31 | 2016 |
| Masterworks on Loan, Celebrating the 100th Anniversary of the Cleveland Museum of Art, "Onement IV" by Barnett Newman | Link | May | 03 | 2016 | August | 14 | 2016 |
| Lynn Hershman Leeson: Cyborgs and Self-Promotion | | March | 10 | 2016 | August | 08 | 2016 |
| Masterworks on Loan, Celebrating the 100th Anniversary of the Cleveland Museum of Art, "Royal Banquet for Celebration of the Fortieth Birthday and Thirty-Year Rule of King Sunjo" | Link | June | 06 | 2016 | October | 09 | 2016 |
| Stag at Sharkey's: George Bellows and the Art of Sports | | May | 14 | 2016 | September | 18 | 2016 |
| Masterworks on Loan, Celebrating the 100th Anniversary of the Cleveland Museum of Art, "White Tara" | Link | April | 06 | 2016 | November | 06 | 2016 |
| BIG: Photographs from the Collection | Link | June | 04 | 2016 | October | 09 | 2016 |
| Masterworks on Loan, Celebrating the 100th Anniversary of the Cleveland Museum of Art, "Four Figures on a Step" by Bartolomé Estaban Murillo | Link | May | 10 | 2016 | July | 24 | 2016 |
| Art and Stories from Mughal India | Link | July | 31 | 2016 | October | 23 | 2016 |
| Masterworks on Loan, Celebrating the 100th Anniversary of the Cleveland Museum of Art, "The Lute Player" by Orazio Gentilechi | Link | October | 17 | 2016 | January | 16 | 2017 |
| Elegance and Intrigue: French Society in 18th-Century Prints and Drawings | | July | 16 | 2016 | November | 06 | 2016 |
| Masterworks on Loan, Celebrating the 100th Anniversary of the Cleveland Museum of Art, "Study for Portrait VI" by Francis Bacon | Link | October | 01 | 2016 | December | 31 | 2016 |
| Dan Graham: Pavilion Compilation | | August | 13 | 2016 | December | 04 | 2016 |
| Masterworks on Loan, Celebrating the 100th Anniversary of the Cleveland Museum of Art, "Madonna at the Fountain" by Jan van Eyck | Link | October | 09 | 2016 | February | 26 | 2017 |
| Dan Graham/Rocks | | August | 13 | 2016 | December | 04 | 2016 |
| Masterworks on Loan, Celebrating the 100th Anniversary of the Cleveland Museum of Art, "A Hunting Scene" by Piero di Cosimo | Link | November | 01 | 2016 | January | 31 | 2017 |
| The Ecstasy of St. Kara | Link | September | 10 | 2016 | December | 31 | 2016 |
| Masterworks on Loan, Celebrating the 100th Anniversary of the Cleveland Museum of Art, "Mask (Kifwebe)" Congo, Luba | Link | March | 25 | 2016 | June | 13 | 2016 |
| The Cleveland Museum of Art Staff Art Show | | December | 16 | 2016 | January | 01 | 2017 |
| Cheating Death: Portrait Photography’s First Half Century | | October | 22 | 2016 | February | 05 | 2017 |
