| Paintings in Oil by Contemporary American Artists | | February | 15 | 1921 | March | 28 | 1921 |
| Miscellaneous Paintings from the [Hinman] Hurlbut, [Horace] Kelley and [William J.] Gordon Collections | | October | 26 | 1921 | November | 16 | 1921 |
| Exhibition of Lace | | March | 03 | 1921 | April | 19 | 1921 |
| Special Exhibition of Work of Pupils in the Public Schools of Japan | | October | 28 | 1921 | November | 29 | 1921 |
| Etchings by Otto H. Bacher | Link | March | 04 | 1921 | April | 07 | 1921 |
| Fine Books and Bindings, designed and executed by Mrs. Rachel Hunt Miller | | November | 14 | 1921 | December | 02 | 1921 |
| Early Italian Engravings | | March | 13 | 1921 | August | 28 | 1921 |
| Charles Shackleton Memorial Exhibition | | November | 15 | 1921 | December | 25 | 1921 |
| Drawings and Sketches by Louis-Maurice Boutet de Monvel | | March | 29 | 1921 | April | 21 | 1921 |
| Etchings and Drypoints by Eileen and George Soper | | November | 16 | 1921 | December | 09 | 1921 |
| Paintings by Gaston [de] LaTouche | | April | 02 | 1921 | April | 27 | 1921 |
| Italian Engravings of the 15th and 16th Centuries | | April | 08 | 1921 | September | 06 | 1921 |
| Italian Textiles | | April | 16 | 1921 | May | 13 | 1921 |
| Third Annual Exhibition of Work by Cleveland Artists and Craftsmen [May Show] | | May | 06 | 1921 | June | 06 | 1921 |
| Laces: J.[eptha] H.Wade's Recent Accessions | | May | 14 | 1921 | October | 31 | 1921 |
| Special Exhibition of Contemporary Japanese Paintings | Link | June | 08 | 1921 | July | 18 | 1921 |
| Special Exhibition of British Arts and Crafts | Link | June | 09 | 1921 | July | 08 | 1921 |
| Etchings by [Lester G.] Hornby, Troy Kinney and [Arthur W.] Heintzelman | | June | 09 | 1921 | July | 08 | 1921 |
| Paintings selected from local canvases produced in the past ten years and from leading spring exhibitions | | June | 10 | 1921 | July | 10 | 1921 |
| Contemporary American Painting | | June | 10 | 1921 | July | 10 | 1921 |
