| Contemporary American Painting | | June | 10 | 1921 | July | 10 | 1921 |
| Paintings by "The Group of Seven," Canadian Painters | | July | 07 | 1921 | August | 31 | 1921 |
| Etchings by Charles A. Platt | | July | 07 | 1921 | September | 29 | 1921 |
| French Painting of the Latter 19th Century | Link | July | 12 | 1921 | September | 15 | 1921 |
| Second Annual Exhibition of the Art and Craftwork of the Cleveland High Schools | | August | | 1921 | November | 20 | 1921 |
| Korean Pottery, a Few Textiles, and Paintings | | August | 31 | 1921 | October | 03 | 1921 |
| Special Exhibition of Work of Students of The Cleveland School of Art | | September | 16 | 1921 | September | 30 | 1921 |
| War Portraits | | October | 01 | 1921 | October | 24 | 1921 |
| Contemporary British Etchers | | October | 02 | 1921 | November | 28 | 1921 |
| Musical Instruments | | October | 09 | 1921 | November | 14 | 1921 |
| Miscellaneous Paintings from the [Hinman] Hurlbut, [Horace] Kelley and [William J.] Gordon Collections | | October | 26 | 1921 | November | 16 | 1921 |
| Illuminations and Printing from Various Lenders | | January | 08 | 1921 | February | 14 | 1921 |
| Special Exhibition of Work of Pupils in the Public Schools of Japan | | October | 28 | 1921 | November | 29 | 1921 |
| Paintings by Arthur H.K. Hammond lent by Dow Chemical Co. | | January | 12 | 1921 | March | 01 | 1921 |
| Fine Books and Bindings, designed and executed by Mrs. Rachel Hunt Miller | | November | 14 | 1921 | December | 02 | 1921 |
| Loan Exhibition of Etchings by Frank W. Benson | | January | 15 | 1921 | March | 03 | 1921 |
| Charles Shackleton Memorial Exhibition | | November | 15 | 1921 | December | 25 | 1921 |
| 17th- and 18th-Century English Rooms | | February | 13 | 1921 | May | 15 | 1921 |
| Etchings and Drypoints by Eileen and George Soper | | November | 16 | 1921 | December | 09 | 1921 |
| Second International Exhibition of Water Colors | | November | 15 | 1922 | December | 15 | 1922 |
