| 17th- and 18th-Century English Rooms | | February | 13 | 1921 | May | 15 | 1921 |
| Paintings in Oil by Contemporary American Artists | | February | 15 | 1921 | March | 28 | 1921 |
| Exhibition of Lace | | March | 03 | 1921 | April | 19 | 1921 |
| Etchings by Otto H. Bacher | Link | March | 04 | 1921 | April | 07 | 1921 |
| Early Italian Engravings | | March | 13 | 1921 | August | 28 | 1921 |
| Drawings and Sketches by Louis-Maurice Boutet de Monvel | | March | 29 | 1921 | April | 21 | 1921 |
| Paintings by Gaston [de] LaTouche | | April | 02 | 1921 | April | 27 | 1921 |
| Japanese Prints: Recent Additions to J. H. Wade | | February | 03 | 1922 | March | 18 | 1922 |
| Renaissance Art | | February | 12 | 1922 | April | | 1922 |
| Lithographs by Joseph Pennell and Henri Fantin-Latour | | March | 03 | 1922 | March | 23 | 1922 |
| American Oil Paintings | | March | 17 | 1922 | April | 10 | 1922 |
| Prints: Gifts of The Print Club | | March | 22 | 1922 | May | 01 | 1922 |
| Paintings by Nicolas Roerich | Link | March | 24 | 1922 | April | 20 | 1922 |
| Etchings, Engravings, Lithographs and Drawings lent by FitzRoy Carrington | | April | 11 | 1922 | April | 26 | 1922 |
| Fourth Annual Exhibition of Work by Cleveland Artists and Craftsmen [May Show] | | May | 01 | 1922 | June | 04 | 1922 |
| Wood blocks and Wood-block Prints by Lepere | | June | 08 | 1922 | June | 29 | 1922 |
| Second Exhibition of Contemporary American Painting | | June | 08 | 1922 | July | 10 | 1922 |
| Contemporary American Etchings | | June | 30 | 1922 | September | 07 | 1922 |
| Prints lent by Salmon P. Halle | | June | 30 | 1922 | September | 07 | 1922 |
| Exhibition of Paintings in CMA Collections, primarily from the Hurlbut Collection | | July | 15 | 1922 | September | 28 | 1922 |
