| Etchings by [Lester G.] Hornby, Troy Kinney and [Arthur W.] Heintzelman | | June | 09 | 1921 | July | 08 | 1921 |
| Etchings and Drypoints by Eileen and George Soper | | November | 16 | 1921 | December | 09 | 1921 |
| Paintings selected from local canvases produced in the past ten years and from leading spring exhibitions | | June | 10 | 1921 | July | 10 | 1921 |
| Exhibition of Lace (1921, 2) | | November | 17 | 1921 | January | 01 | 1922 |
| Contemporary American Painting | | June | 10 | 1921 | July | 10 | 1921 |
| Special Exhibition of Laces from an Eastern Estate | | November | 18 | 1921 | January | 12 | 1922 |
| Paintings by "The Group of Seven," Canadian Painters | | July | 07 | 1921 | August | 31 | 1921 |
| Western Etchings by George Elbert Burr, Charles W. Dahlgreen, Ralph M. Pearson, and B.[ror]J. Nordfelt | | November | 29 | 1921 | January | 05 | 1922 |
| Etchings by Charles A. Platt | | July | 07 | 1921 | September | 29 | 1921 |
| French Painting of the Latter 19th Century | Link | July | 12 | 1921 | September | 15 | 1921 |
| Second Annual Exhibition of the Art and Craftwork of the Cleveland High Schools | | August | | 1921 | November | 20 | 1921 |
| Illuminations and Printing from Various Lenders | | January | 08 | 1921 | February | 14 | 1921 |
| Paintings by Arthur H.K. Hammond lent by Dow Chemical Co. | | January | 12 | 1921 | March | 01 | 1921 |
| Loan Exhibition of Etchings by Frank W. Benson | | January | 15 | 1921 | March | 03 | 1921 |
| 17th- and 18th-Century English Rooms | | February | 13 | 1921 | May | 15 | 1921 |
| Paintings in Oil by Contemporary American Artists | | February | 15 | 1921 | March | 28 | 1921 |
| Exhibition of Lace | | March | 03 | 1921 | April | 19 | 1921 |
| Etchings by Otto H. Bacher | Link | March | 04 | 1921 | April | 07 | 1921 |
| Early Italian Engravings | | March | 13 | 1921 | August | 28 | 1921 |
| Tapestries: Set of the History of Jacob, Joseph, and Pharaoh, lent by Salmon P. Halle | | July | 15 | 1922 | November | 01 | 1922 |
