| Etchings by [Lester G.] Hornby, Troy Kinney and [Arthur W.] Heintzelman | | June | 09 | 1921 | July | 08 | 1921 |
| Miscellaneous Paintings from the [Hinman] Hurlbut, [Horace] Kelley and [William J.] Gordon Collections | | October | 26 | 1921 | November | 16 | 1921 |
| Paintings selected from local canvases produced in the past ten years and from leading spring exhibitions | | June | 10 | 1921 | July | 10 | 1921 |
| Special Exhibition of Work of Pupils in the Public Schools of Japan | | October | 28 | 1921 | November | 29 | 1921 |
| Contemporary American Painting | | June | 10 | 1921 | July | 10 | 1921 |
| Fine Books and Bindings, designed and executed by Mrs. Rachel Hunt Miller | | November | 14 | 1921 | December | 02 | 1921 |
| Paintings by "The Group of Seven," Canadian Painters | | July | 07 | 1921 | August | 31 | 1921 |
| Charles Shackleton Memorial Exhibition | | November | 15 | 1921 | December | 25 | 1921 |
| Etchings by Charles A. Platt | | July | 07 | 1921 | September | 29 | 1921 |
| Etchings and Drypoints by Eileen and George Soper | | November | 16 | 1921 | December | 09 | 1921 |
| French Painting of the Latter 19th Century | Link | July | 12 | 1921 | September | 15 | 1921 |
| Second Annual Exhibition of the Art and Craftwork of the Cleveland High Schools | | August | | 1921 | November | 20 | 1921 |
| Etchings and Lithographs by Mary Cassatt and Artists of the Barbizon School | | December | 11 | 1920 | January | 11 | 1921 |
| Prints from the Modern French School | | December | 11 | 1920 | January | 12 | 1921 |
| Musical Instruments, The Charles G. King, Jr. Collection | | December | 29 | 1920 | April | 4 | 1921 |
| Illuminations and Printing from Various Lenders | | January | 08 | 1921 | February | 14 | 1921 |
| Paintings by Arthur H.K. Hammond lent by Dow Chemical Co. | | January | 12 | 1921 | March | 01 | 1921 |
| Loan Exhibition of Etchings by Frank W. Benson | | January | 15 | 1921 | March | 03 | 1921 |
| 17th- and 18th-Century English Rooms | | February | 13 | 1921 | May | 15 | 1921 |
| Paintings in Oil by Contemporary American Artists | | February | 15 | 1921 | March | 28 | 1921 |
