| Etchings by Charles A. Platt | | July | 07 | 1921 | September | 29 | 1921 |
| French Painting of the Latter 19th Century | Link | July | 12 | 1921 | September | 15 | 1921 |
| Second Annual Exhibition of the Art and Craftwork of the Cleveland High Schools | | August | | 1921 | November | 20 | 1921 |
| Illuminations and Printing from Various Lenders | | January | 08 | 1921 | February | 14 | 1921 |
| Paintings by Arthur H.K. Hammond lent by Dow Chemical Co. | | January | 12 | 1921 | March | 01 | 1921 |
| Loan Exhibition of Etchings by Frank W. Benson | | January | 15 | 1921 | March | 03 | 1921 |
| 17th- and 18th-Century English Rooms | | February | 13 | 1921 | May | 15 | 1921 |
| Paintings in Oil by Contemporary American Artists | | February | 15 | 1921 | March | 28 | 1921 |
| Exhibition of Lace | | March | 03 | 1921 | April | 19 | 1921 |
| Etchings by Otto H. Bacher | Link | March | 04 | 1921 | April | 07 | 1921 |
| Early Italian Engravings | | March | 13 | 1921 | August | 28 | 1921 |
| Korean Pottery, a Few Textiles, and Paintings | | August | 31 | 1921 | October | 03 | 1921 |
| Drawings and Sketches by Louis-Maurice Boutet de Monvel | | March | 29 | 1921 | April | 21 | 1921 |
| Special Exhibition of Work of Students of The Cleveland School of Art | | September | 16 | 1921 | September | 30 | 1921 |
| Paintings by Gaston [de] LaTouche | | April | 02 | 1921 | April | 27 | 1921 |
| War Portraits | | October | 01 | 1921 | October | 24 | 1921 |
| Italian Engravings of the 15th and 16th Centuries | | April | 08 | 1921 | September | 06 | 1921 |
| Contemporary British Etchers | | October | 02 | 1921 | November | 28 | 1921 |
| Italian Textiles | | April | 16 | 1921 | May | 13 | 1921 |
| Special Exhibition of American Silks Made and Lent by Cheney Brothers | | October | 20 | 1922 | October | 31 | 1922 |
